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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesRattus norvegicus (Rat)
GeneHtr2a
Synonym5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
'D' receptor
5-HT-2A
serotonin receptor 2A
5Ht-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length471
Amino acid sequenceMEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProtP14842
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL322
IUPHAR6
DrugBankN/A

Ligand

Name4-(4-Fluorobenzoyl)piperidine
Molecular formulaC12H14FNO
IUPAC name(4-fluorophenyl)-piperidin-4-ylmethanone
Molecular weight207.248
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP1.7
Synonyms56346-57-7
(4-fluorophenyl)(piperidin-4-yl)methanone
4- (4-Fluorobenzoyl)-piperidine
4-(4-fluoro-benzoyl)-piperidine
(4-Fluoro-phenyl)-piperidin-4-yl-methanone
[ Show all ]
Inchi KeyABERUOJGWHYBJL-UHFFFAOYSA-N
Inchi IDInChI=1S/C12H14FNO/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10/h1-4,10,14H,5-8H2
PubChem CID2724440
ChEMBLCHEMBL148189
IUPHARN/A
BindingDB50004316
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Kd524.81 nMBioorg. Med. Chem. Lett., (1995) 5:7:667ChEMBL
Ki398.0 nMN/ABindingDB
Ki398.11 nMBioorg. Med. Chem. Lett., (1995) 5:7:667ChEMBL

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