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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1997793
Molecular formulaC24H22N2O5S
IUPAC name4-(4-ethoxyphenoxy)-5-methylsulfonyl-2-(naphthalen-1-ylmethyl)pyridazin-3-one
Molecular weight450.509
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.7
SynonymsSR-02000001222
SR-02000001222-1
Inchi KeyFHKKBMRSYQABSU-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H22N2O5S/c1-3-30-19-11-13-20(14-12-19)31-23-22(32(2,28)29)15-25-26(24(23)27)16-18-9-6-8-17-7-4-5-10-21(17)18/h4-15H,3,16H2,1-2H3
PubChem CID53230266
ChEMBLCHEMBL1997793
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC502550.0 nMPubChem BioAssay data setChEMBL

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