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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL1223709
Molecular formulaC29H32ClN5O
IUPAC nameN-[3-[1-[3-[[1-(3-chlorophenyl)benzimidazol-2-yl]amino]propyl]piperidin-4-yl]phenyl]acetamide
Molecular weight502.059
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP5.9
SynonymsSCHEMBL13901461
BDBM50325945
N-(3-(1-(3-(1-(3-chlorophenyl)-1H-benzo[d]imidazol-2-ylamino)propyl)piperidin-4-yl)phenyl)acetamide
Inchi KeyAKSZOVIZULWYMI-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H32ClN5O/c1-21(36)32-25-9-4-7-23(19-25)22-13-17-34(18-14-22)16-6-15-31-29-33-27-11-2-3-12-28(27)35(29)26-10-5-8-24(30)20-26/h2-5,7-12,19-20,22H,6,13-18H2,1H3,(H,31,33)(H,32,36)
PubChem CID49865653
ChEMBLCHEMBL1223709
IUPHARN/A
BindingDB50325945
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5045.0 nMPMID20724156BindingDB,ChEMBL
IC50110.0 nMPMID20724156BindingDB,ChEMBL

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