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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL136622
Molecular formula	C23H30FNO
IUPAC name	2-(4-fluorophenyl)-1-[1-(4-phenylbutyl)piperidin-4-yl]ethanol
Molecular weight	355.497
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.1
Synonyms	2-(4-Fluoro-phenyl)-1-[1-(4-phenyl-butyl)-piperidin-4-yl]-ethanol BDBM50002271 2-(4-Fluorophenyl)-1-[1-(4-phenylbutyl)piperidin-4-yl]ethanol
Inchi Key	FIFLUTNSIVHHPL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H30FNO/c24-22-11-9-20(10-12-22)18-23(26)21-13-16-25(17-14-21)15-5-4-8-19-6-2-1-3-7-19/h1-3,6-7,9-12,21,23,26H,4-5,8,13-18H2
PubChem CID	10089567
ChEMBL	CHEMBL136622
IUPHAR	N/A
BindingDB	50002271
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	900.0 nM	PMID1360026	BindingDB,ChEMBL

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