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GLASS

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GPCR

Name	Relaxin receptor 1
Species	Homo sapiens (Human)
Gene	RXFP1
Synonym	Relaxin family peptide receptor 1 RX1 relaxin/insulin like family peptide receptor 1 relaxin receptor 1 RXFPR1 LGR7 leucine-rich repeat-containing G-protein-coupled receptor 7 Leucine-rich repeat-containing G-protein coupled receptor 7 RXFP1 [ Show all ]
Disease	Acute heart failure
Length	757
Amino acid sequence	MTSGSVFFYILIFGKYFSHGGGQDVKCSLGYFPCGNITKCLPQLLHCNGVDDCGNQADEDNCGDNNGWSLQFDKYFASYYKMTSQYPFEAETPECLVGSVPVQCLCQGLELDCDETNLRAVPSVSSNVTAMSLQWNLIRKLPPDCFKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLIIEDNHLSRISPPTFYGLNSLILLVLMNNVLTRLPDKPLCQHMPRLHWLDLEGNHIHNLRNLTFISCSNLTVLVMRKNKINHLNENTFAPLQKLDELDLGSNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMFRPLMNLSHIYFKKFQYCGYAPHVRSCKPNTDGISSLENLLASIIQRVFVWVVSAVTCFGNIFVICMRPYIRSENKLYAMSIISLCCADCLMGIYLFVIGGFDLKFRGEYNKHAQLWMESTHCQLVGSLAILSTEVSVLLLTFLTLEKYICIVYPFRCVRPGKCRTITVLILIWITGFIVAFIPLSNKEFFKNYYGTNGVCFPLHSEDTESIGAQIYSVAIFLGINLAAFIIIVFSYGSMFYSVHQSAITATEIRNQVKKEMILAKRFFFIVFTDALCWIPIFVVKFLSLLQVEIPGTITSWVVIFILPINSALNPILYTLTTRPFKEMIHRFWYNYRQRKSMDSKGQKTYAPSFIWVEMWPLQEMPPELMKPDLFTYPCEMSLISQSTRLNSYS
UniProt	Q9HBX9
Protein Data Bank	2jm4
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2jm4.
BioLiP	BL0101296
Therapeutic Target Database	T73696
ChEMBL	CHEMBL1293316
IUPHAR	351
DrugBank	N/A

Ligand

Name	AC1OBTDF
Molecular formula	C19H15BrN4O3
IUPAC name	5-bromo-N-[(E)-(1,3-dimethyl-2-oxobenzimidazol-5-yl)methylideneamino]-1-benzofuran-2-carboxamide
Molecular weight	427.258
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.3
Synonyms	5-bromo-N-[(E)-(1,3-dimethyl-2-oxobenzimidazol-5-yl)methylideneamino]-1-benzofuran-2-carboxamide SMR000436137 AKOS003207594 5-Bromo-benzofuran-2-carboxylic acid [1-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-meth-(E)-ylidene]-hydrazide MLS000332847 577984-49-7 STL302233 5-bromo-N'-[(E)-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)methylidene]-1-benzofuran-2-carbohydrazide MolPort-002-602-020 ZINC33304971 CHEMBL3192586 [ Show all ]
Inchi Key	AKVYGNSBGGRHHG-UFFVCSGVSA-N
Inchi ID	InChI=1S/C19H15BrN4O3/c1-23-14-5-3-11(7-15(14)24(2)19(23)26)10-21-22-18(25)17-9-12-8-13(20)4-6-16(12)27-17/h3-10H,1-2H3,(H,22,25)/b21-10+
PubChem CID	6886091
ChEMBL	CHEMBL3192586
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	35481.3 nM	PubChem BioAssay data set	ChEMBL

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