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GPCR

NameAlpha-1A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA1A
SynonymAlpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Alpha-1A adrenoceptor
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
UniProtP18130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4892
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL156283
Molecular formulaC10H15N3
IUPAC name1,4,5,7,8,9,10,10a-octahydropyrazolo[3,4-a]quinolizine
Molecular weight177.251
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP1.0
SynonymsPyrazolo[3,4-a]quinolizine, 1,4,5,7,8,9,10,10a-octahydro-
BDBM50018734
AKOS030261762
112114-04-2
1,4,5,7,8,9,10,10a-Octahydro-pyrazolo[3,4-a]quinolizine
Inchi KeyFIWQPBGSTABWLI-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H15N3/c1-2-5-13-6-4-8-7-11-12-10(8)9(13)3-1/h7,9H,1-6H2,(H,11,12)
PubChem CID14004033
ChEMBLCHEMBL156283
IUPHARN/A
BindingDB50018734
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki23988.0 nMPMID2831365BindingDB
Ki23988.3 nMPMID2831365ChEMBL
Ki24000.0 nMPMID2831365BindingDB,ChEMBL

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