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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL266412
Molecular formulaC153H224N42O47S
IUPAC name(3S)-3-[[(2S)-5-amino-2-[2-[[(3R,6S,9S,17R)-9-[[(2R)-2-[[(2R)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R,3S)-2-[[(2R)-2-[[(2R,3S)-2-[[2-[[(2R)-5-amino-2-[[(2R)-2-[[(2R)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-[3-(diaminomethylideneamino)propyl]-6-(hydroxymethyl)-2,5,8,11-tetraoxo-1,4,7,12-tetrazacycloheptadecane-17-carbonyl]amino]propanoylamino]-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3435.78
Hydrogen bond acceptor52
Hydrogen bond donor51
XlogP-16.4
SynonymsN/A
Inchi KeyFJTIBBQXMITNCF-XEYSRJMFSA-N
Inchi IDInChI=1S/C153H224N42O47S/c1-73(2)53-98(135(225)175-97(48-52-243-11)134(224)183-105(61-116(159)208)145(235)194-122(77(8)200)125(160)215)178-139(229)104(59-84-65-166-90-30-19-18-29-88(84)90)182-133(223)96(44-47-115(158)207)176-150(240)121(75(5)6)193-143(233)102(55-80-25-14-12-15-26-80)181-141(231)107(63-119(211)212)185-132(222)95(43-46-114(157)206)170-126(216)76(7)169-129(219)91-32-21-23-50-164-117(209)62-106(140(230)190-111(70-198)148(238)173-93(130(220)171-91)33-24-51-165-153(161)162)184-136(226)99(54-74(3)4)177-137(227)100(57-82-34-38-86(203)39-35-82)179-131(221)92(31-20-22-49-154)172-147(237)110(69-197)189-138(228)101(58-83-36-40-87(204)41-37-83)180-142(232)108(64-120(213)214)186-149(239)112(71-199)191-152(242)124(79(10)202)195-144(234)103(56-81-27-16-13-17-28-81)187-151(241)123(78(9)201)192-118(210)67-167-128(218)94(42-45-113(156)205)174-146(236)109(68-196)188-127(217)89(155)60-85-66-163-72-168-85/h12-19,25-30,34-41,65-66,72-79,89,91-112,121-124,166,196-204H,20-24,31-33,42-64,67-71,154-155H2,1-11H3,(H2,156,205)(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,215)(H,163,168)(H,164,209)(H,167,218)(H,169,219)(H,170,216)(H,171,220)(H,172,237)(H,173,238)(H,174,236)(H,175,225)(H,176,240)(H,177,227)(H,178,229)(H,179,221)(H,180,232)(H,181,231)(H,182,223)(H,183,224)(H,184,226)(H,185,222)(H,186,239)(H,187,241)(H,188,217)(H,189,228)(H,190,230)(H,191,242)(H,192,210)(H,193,233)(H,194,235)(H,195,234)(H,211,212)(H,213,214)(H4,161,162,165)/t76?,77-,78+,79+,89-,91-,92-,93-,94-,95+,96+,97+,98+,99-,100-,101-,102+,103-,104+,105+,106+,107+,108-,109-,110-,111+,112-,121+,122+,123-,124-/m1/s1
PubChem CID77077838
ChEMBLN/A
IUPHARN/A
BindingDB50087846
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC501500.0 nMPMID10794689BindingDB

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