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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL9071
Molecular formulaC36H52Br2N4O4
IUPAC name[3-(1,3-dioxoisoindol-2-yl)-2,2-dimethylpropyl]-[6-[[3-(1,3-dioxoisoindol-2-yl)-2,2-dimethylpropyl]-dimethylazaniumyl]hexyl]-dimethylazanium;dibromide
Molecular weight764.644
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogPNone
SynonymsN/A
Inchi KeyFJWHITLBPJDATN-UHFFFAOYSA-L
Inchi IDInChI=1S/C36H52N4O4.2BrH/c1-35(2,23-37-31(41)27-17-11-12-18-28(27)32(37)42)25-39(5,6)21-15-9-10-16-22-40(7,8)26-36(3,4)24-38-33(43)29-19-13-14-20-30(29)34(38)44;;/h11-14,17-20H,9-10,15-16,21-26H2,1-8H3;2*1H/q+2;;/p-2
PubChem CID10974719
ChEMBLCHEMBL9071
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
-logKa7.08 -PMID12620079ChEMBL
EC50177.83 nMPMID12620079ChEMBL
p alphaKa6.87 -PMID12620079ChEMBL
pAlpha-0.21 -PMID12620079ChEMBL

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