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Name | Metabotropic glutamate receptor 5 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Grm5 |
Synonym | glutamate receptor GPRC1E mGlu5 receptor mGluR5 |
Disease | N/A for non-human GPCRs |
Length | 1203 |
Amino acid sequence | MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTENRGPGAAAGGGSGPGVAGAGNAGCTATGGPEPPDAGPKALYDVAEAEESFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANISELNSMMLSTAATPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQGATGVSPAQETPTGAESAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL |
UniProt | P31424 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2564 |
IUPHAR | 293 |
DrugBank | N/A |
Name | CHEMBL181483 |
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Molecular formula | C15H10N2 |
IUPAC name | 3-[2-(6-methylpyridin-2-yl)ethynyl]benzonitrile |
Molecular weight | 218.259 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 3.0 |
Synonyms | 3-[(6-Methylpyridin-2-yl)ethynyl]benzonitrile SCHEMBL4711543 BDBM50160632 D0F2KL 3-[2-(6-Methylpyridin-2-yl)ethynyl]-benzonitrile [ Show all ] |
Inchi Key | FKODYULBKPINFM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H10N2/c1-12-4-2-7-15(17-12)9-8-13-5-3-6-14(10-13)11-16/h2-7,10H,1H3 |
PubChem CID | 11378977 |
ChEMBL | CHEMBL181483 |
IUPHAR | N/A |
BindingDB | 50160632 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.415 nM | PMID19445453 | ChEMBL |
IC50 | 0.42 nM | PMID19445453 | BindingDB |
IC50 | 5.0 nM | PMID15686891 | BindingDB,ChEMBL |
IC50 | 13.0 nM | PMID22924094 | BindingDB,ChEMBL |
Ki | 1.04 nM | PMID22924094 | BindingDB,ChEMBL |
Ki | 1.3 nM | PMID19445453 | BindingDB,ChEMBL |
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