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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3113623
Molecular formula	C23H28N6O4S
IUPAC name	5-[4-[6-(5-methylsulfonyl-2,3-dihydroindol-1-yl)pyrimidin-4-yl]oxypiperidin-1-yl]-3-propan-2-yl-1,2,4-oxadiazole
Molecular weight	484.575
Hydrogen bond acceptor	10
Hydrogen bond donor	0
XlogP	3.9
Synonyms	SCHEMBL515149 5-(Methylsulfonyl)-1-[6-[[1-[3-(propane-2-yl)-1,2,4-oxadiazole-5-yl]piperidine-4-yl]oxy]pyrimidine-4-yl]-2,3-dihydro-1H-indole BDBM50446691
Inchi Key	ALAMXYQQAKXSLD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H28N6O4S/c1-15(2)22-26-23(33-27-22)28-9-7-17(8-10-28)32-21-13-20(24-14-25-21)29-11-6-16-12-18(34(3,30)31)4-5-19(16)29/h4-5,12-15,17H,6-11H2,1-3H3
PubChem CID	46897575
ChEMBL	CHEMBL3113623
IUPHAR	N/A
BindingDB	50446691
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7.7 nM	PMID24508142	BindingDB,ChEMBL

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