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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin F2-alpha receptor
Species	Homo sapiens (Human)
Gene	PTGFR
Synonym	Prostanoid FP receptor prostaglandin F2-alpha receptor prostaglandin F receptor (FP) prostaglandin F receptor PGF2-alpha receptor PGF2 alpha receptor PGF receptor PF2AR FP receptor [ Show all ]
Disease	Glaucoma Ocular disease Renal cancer Dysmenorrhea Alzheimer disease Aborting pregnancy Open-angle glaucoma; Ocular hypertension [ Show all ]
Length	359
Amino acid sequence	MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMKAYQRFRQKSKASFLLLASGLVITDFFGHLINGAIAVFVYASDKEWIRFDQSNVLCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGVCLFAVFIALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLALGVSLLCNAITGITLLRVKFKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFLVTMANIGINGNHSLETCETTLFALRMATWNQILDPWVYILLRKAVLKNLYKLASQCCGVHVISLHIWELSSIKNSLKVAAISESPVAEKSAST
UniProt	P43088
Protein Data Bank	N/A
GPCR-HGmod model	P43088
3D structure model	This predicted structure model is from GPCR-EXP P43088.
BioLiP	N/A
Therapeutic Target Database	T75797
ChEMBL	CHEMBL1987
IUPHAR	344
DrugBank	BE0000610

Ligand

Name	CHEMBL1079732
Molecular formula	C22H13Cl4FN4O3S2
IUPAC name	4,5-dichloro-N-[5-[1-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methylindol-7-yl]-1,2,4-oxadiazol-3-yl]thiophene-2-sulfonamide
Molecular weight	606.289
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	7.7
Synonyms	BDBM50311612 4,5-dichloro-N-(5-(1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl)-1,2,4-oxadiazol-3-yl)thiophene-2-sulfonamide
Inchi Key	FKSFUQRGCQKPTK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H13Cl4FN4O3S2/c1-10-8-31(9-11-2-3-12(23)4-16(11)24)19-14(10)5-13(27)6-15(19)21-28-22(29-34-21)30-36(32,33)18-7-17(25)20(26)35-18/h2-8H,9H2,1H3,(H,29,30)
PubChem CID	46879719
ChEMBL	CHEMBL1079732
IUPHAR	N/A
BindingDB	50311612
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Activity	-4.0 %	PMID19836233	ChEMBL
Activity	-2.0 %	PMID19836233	ChEMBL
Activity	30.0 %	PMID19836233	ChEMBL

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