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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesSus scrofa (Pig)
GeneHTR1D
Synonym5-HT-1D
5-HT1D
Serotonin receptor 1D
DiseaseN/A for non-human GPCRs
Length291
Amino acid sequenceAMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProtP79400
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4105
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL53764
Molecular formulaC16H20N4
IUPAC nameN,N-dimethyl-2-[5-(2-methylimidazol-1-yl)-1H-indol-3-yl]ethanamine
Molecular weight268.364
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP2.5
SynonymsBDBM50407361
N,N-Dimethyl-5-(2-methyl-1H-imidazol-1-yl)-1H-indole-3-(ethanamine)
SCHEMBL8784710
Inchi KeyFKWIKKLASAZVLL-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H20N4/c1-12-17-7-9-20(12)14-4-5-16-15(10-14)13(11-18-16)6-8-19(2)3/h4-5,7,9-11,18H,6,8H2,1-3H3
PubChem CID10468253
ChEMBLCHEMBL53764
IUPHARN/A
BindingDB50407361
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC507.94 nMPMID7752204BindingDB
IC507.943 nMPMID7752204ChEMBL

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