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GPCR

Name5-hydroxytryptamine receptor 1B
SpeciesRattus norvegicus (Rat)
GeneHtr1b
Synonym5-HT1B
Serotonin receptor 1B
5-HT-1B
5-HT1B receptor
5-HT1DB
[ Show all ]
DiseaseN/A for non-human GPCRs
Length386
Amino acid sequenceMEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG
UniProtP28564
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3459
IUPHAR2
DrugBankN/A

Ligand

NameCHEMBL291620
Molecular formulaC18H29NO
IUPAC name8-methoxy-5-methyl-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
Molecular weight275.436
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP4.8
SynonymsBDBM50280936
(8-Methoxy-5-methyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-dipropyl-amine
Inchi KeyALBKVCFLVIPHKO-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H29NO/c1-5-11-19(12-6-2)15-8-9-16-14(3)7-10-18(20-4)17(16)13-15/h7,10,15H,5-6,8-9,11-13H2,1-4H3
PubChem CID44304338
ChEMBLCHEMBL291620
IUPHARN/A
BindingDB50280936
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki575.0 nM, Bioorg. Med. Chem. Lett., (1993) 3:10:2035BindingDB,ChEMBL

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