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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1B) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD5
Synonym	Gpcr1 DRD1L2 DRD1B dopamine receptor 5 Dopamine D5 receptor D5 receptor D1beta dopamine receptor D(5) dopamine receptor D(1B) dopamine receptor [ Show all ]
Disease	Solid tumours Schizophrenia
Length	477
Amino acid sequence	MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProt	P21918
Protein Data Bank	N/A
GPCR-HGmod model	P21918
3D structure model	This predicted structure model is from GPCR-EXP P21918.
BioLiP	N/A
Therapeutic Target Database	T46828
ChEMBL	CHEMBL1850
IUPHAR	218
DrugBank	BE0000145, BE0004889

Ligand

Name	CHEMBL3289647
Molecular formula	C19H24FN3S
IUPAC name	1-[3-(4-fluorophenyl)sulfanylpropyl]-4-(5-methylpyridin-2-yl)piperazine
Molecular weight	345.48
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.1
Synonyms	BDBM50017970
Inchi Key	FLNJSRMYQSEHEU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H24FN3S/c1-16-3-8-19(21-15-16)23-12-10-22(11-13-23)9-2-14-24-18-6-4-17(20)5-7-18/h3-8,15H,2,9-14H2,1H3
PubChem CID	90644062
ChEMBL	CHEMBL3289647
IUPHAR	N/A
BindingDB	50017970
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1995.26 nM	PMID24800940	ChEMBL
Ki	2159.0 nM	PMID24800940	BindingDB,ChEMBL

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