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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Homo sapiens (Human)
Gene	TRHR
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	Unspecified Pain Neurodegenerative disease Endocrine disease Cognitive disorders CNS stimulant [ Show all ]
Length	398
Amino acid sequence	MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProt	P34981
Protein Data Bank	N/A
GPCR-HGmod model	P34981
3D structure model	This predicted structure model is from GPCR-EXP P34981.
BioLiP	N/A
Therapeutic Target Database	T77796
ChEMBL	CHEMBL1810
IUPHAR	363
DrugBank	BE0008659

Ligand

Name	3-(trifluoromethyl)benzo[g]quinoxalin-2-ol
Molecular formula	C13H7F3N2O
IUPAC name	3-(trifluoromethyl)-1H-benzo[g]quinoxalin-2-one
Molecular weight	264.207
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.1
Synonyms	FLOKVRACNNBAGH-UHFFFAOYSA-N ST084077 A3422/0145217 BDBM67432 MLS000686612 CHEMBL1469407 SR-01000736939 3-(trifluoromethyl)-1H-benzo[g]quinoxalin-2-one HMS2715A21 STK683085 AC1LT5KK Benzo[g]quinoxalin-2-ol, 3-trifluoromethyl- MolPort-002-725-751 cid_1502798 SR-01000736939-2 MCULE-3788255278 ZINC5889485 AKOS001734203 SMR000315133 [ Show all ]
Inchi Key	FLOKVRACNNBAGH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H7F3N2O/c14-13(15,16)11-12(19)18-10-6-8-4-2-1-3-7(8)5-9(10)17-11/h1-6H,(H,18,19)
PubChem CID	1502798
ChEMBL	CHEMBL1469407
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	2909.3 nM	PubChem BioAssay data set	ChEMBL

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