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GPCR

NameEndothelin receptor type B
SpeciesSus scrofa (Pig)
GeneEDNRB
SynonymEndothelin receptor non-selective type
ET-B
ET-BR
DiseaseN/A for non-human GPCRs
Length443
Amino acid sequenceMQPLRSLCGRALVALIFACGVAGVQSEERGFPPAGATPPALRTGEIVAPPTKTFWPRGSNASLPRSSSPPQMPKGGRMAGPPARTLTPPPCEGPIEIKDTFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEALGFDMITTDYKGNRLRICLLHPTQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYDQNDSNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
UniProtP35463
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3949
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL65353
Molecular formulaC25H26O6
IUPAC name2-(1,3-benzodioxol-5-yl)-4-cyclopentyl-6-propan-2-yloxy-2H-chromene-3-carboxylic acid
Molecular weight422.477
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP5.3
SynonymsBDBM50112675
SCHEMBL7943835
2-Benzo[1,3]dioxol-5-yl-4-cyclopentyl-6-isopropoxy-2H-chromene-3-carboxylic acid
Inchi KeyFMCJZFZHWFVXMF-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H26O6/c1-14(2)30-17-8-10-19-18(12-17)22(15-5-3-4-6-15)23(25(26)27)24(31-19)16-7-9-20-21(11-16)29-13-28-20/h7-12,14-15,24H,3-6,13H2,1-2H3,(H,26,27)
PubChem CID10982740
ChEMBLCHEMBL65353
IUPHARN/A
BindingDB50112675
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50350.0 nMPMID11985472BindingDB,ChEMBL

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