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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL103753
Molecular formula	C26H26N4O2
IUPAC name	2-[4-(3-hydroxy-3,3-diphenylpropanoyl)piperazin-1-yl]-2-pyridin-3-ylacetonitrile
Molecular weight	426.52
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	2.2
Synonyms	[4-(3-Hydroxy-3,3-diphenyl-propionyl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile [4-(3-Hydroxy-3,3-diphenyl-propionyl)-piperazin-1-yl]-pyridin-3-yl-acetonitrile; hydrate BDBM50003510 SCHEMBL9852905
Inchi Key	FMTWOXJEAYZPIZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H26N4O2/c27-19-24(21-8-7-13-28-20-21)29-14-16-30(17-15-29)25(31)18-26(32,22-9-3-1-4-10-22)23-11-5-2-6-12-23/h1-13,20,24,32H,14-18H2
PubChem CID	10410208
ChEMBL	CHEMBL103753
IUPHAR	N/A
BindingDB	50003510
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	0.061 mg.kg-1	PMID1433215, PMID8411016	ChEMBL

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