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GPCR

NameG-protein coupled receptor 35
SpeciesHomo sapiens (Human)
GeneGPR35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A
Length309
Amino acid sequenceMNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProtQ9HC97
Protein Data BankN/A
GPCR-HGmod modelQ9HC97
3D structure modelThis predicted structure model is from GPCR-EXP Q9HC97.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293267
IUPHAR102
DrugBankBE0005562

Ligand

NameCHEMBL2037467
Molecular formulaC11H11NO2S
IUPAC name3-cyclopropyl-6-methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Molecular weight221.274
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.0
SynonymsBDBM50385241
Inchi KeyFMVDSUJWEDWDQD-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H11NO2S/c1-5-8(11(13)14)12-9-7(6-2-3-6)4-15-10(5)9/h4,6,12H,2-3H2,1H3,(H,13,14)
PubChem CID70681839
ChEMBLCHEMBL2037467
IUPHARN/A
BindingDB50385241
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC508370.0 nMPMID22572579BindingDB,ChEMBL
EC50119000.0 nMPMID22572579BindingDB,ChEMBL
Efficacy35.0 %PMID22572579ChEMBL
Efficacy228.0 %PMID22572579ChEMBL

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