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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Ligand

NameMLS000779148
Molecular formulaC16H9N3O4S
IUPAC name(6E)-6-[(6-hydroxy-4-oxochromen-3-yl)methylidene]-5-imino-[1,3]thiazolo[3,2-a]pyrimidin-7-one
Molecular weight339.325
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.5
Synonyms3-[(E)-(5-iminio-7-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidin-6(7H)-ylidene)methyl]-4-oxo-4H-chromen-6-olate
CHEMBL1543251
ZINC5442848
(6E)-5-azanylidene-6-[(6-oxidanyl-4-oxidanylidene-chromen-3-yl)methylidene]-[1,3]thiazolo[3,2-a]pyrimidin-7-one
AC1LZUHQ
[ Show all ]
Inchi KeyFNEJQEBATASNNC-UTVFFRKMSA-N
Inchi IDInChI=1S/C16H9N3O4S/c17-14-11(15(22)18-16-19(14)3-4-24-16)5-8-7-23-12-2-1-9(20)6-10(12)13(8)21/h1-7,17,20H/b11-5+,17-14?
PubChem CID1958984
ChEMBLCHEMBL1543251
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Potency9200.0 nMPubChem BioAssay data setChEMBL

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