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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neurotensin receptor type 2
Species	Rattus norvegicus (Rat)
Gene	Ntsr2
Synonym	NTRL NTR2 NT2R NT-R-2 neurotensin receptor type 2 levocabastine-sensitive neurotensin receptor High-affinity levocabastine-sensitive neurotensin receptor NTS2 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	416
Amino acid sequence	METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKARAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAYATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEVESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQVPSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLRAIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNAVSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV
UniProt	Q63384
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5106
IUPHAR	310
DrugBank	N/A

Ligand

Name	CHEMBL3290106
Molecular formula	C24H24FN3O4
IUPAC name	1-[[1-(4-fluorophenyl)-5-(2-methoxyphenyl)pyrazole-3-carbonyl]amino]cyclohexane-1-carboxylic acid
Molecular weight	437.471
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.4
Synonyms	SCHEMBL17114579 BDBM50019424 NTRC-739
Inchi Key	FNMJXTBTWXLVJG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H24FN3O4/c1-32-21-8-4-3-7-18(21)20-15-19(27-28(20)17-11-9-16(25)10-12-17)22(29)26-24(23(30)31)13-5-2-6-14-24/h3-4,7-12,15H,2,5-6,13-14H2,1H3,(H,26,29)(H,30,31)
PubChem CID	90644399
ChEMBL	CHEMBL3290106
IUPHAR	N/A
BindingDB	50019424
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7.0 nM	PMID24856674	ChEMBL
EC50	7.0 nM	PMID24856674	BindingDB
EC50	12.0 nM	PMID24856674	BindingDB,ChEMBL
IC50	153.0 nM	PMID24856674	BindingDB,ChEMBL
Ki	153.0 nM	PMID24856674	BindingDB,ChEMBL

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