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GPCR

NameGalanin receptor type 1
SpeciesHomo sapiens (Human)
GeneGALR1
SynonymGAL1-R
GALNR
GALNR1
GALR-1
GAL1 receptor
DiseaseEpileptic seizures
Length349
Amino acid sequenceMELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProtP47211
Protein Data BankN/A
GPCR-HGmod modelP47211
3D structure modelThis predicted structure model is from GPCR-EXP P47211.
BioLiPN/A
Therapeutic Target DatabaseT78581
ChEMBLCHEMBL4894
IUPHAR243
DrugBankN/A

Ligand

NameCHEMBL1922004
Molecular formulaC24H29N5O
IUPAC name4-N-(2,4-dimethylphenyl)-2-N-(4-methoxyphenyl)-6-piperidin-1-ylpyrimidine-2,4-diamine
Molecular weight403.53
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP6.0
SynonymsBDBM50358674
SCHEMBL10143393
Inchi KeyFOGIYCFXQGFUDY-UHFFFAOYSA-N
Inchi IDInChI=1S/C24H29N5O/c1-17-7-12-21(18(2)15-17)26-22-16-23(29-13-5-4-6-14-29)28-24(27-22)25-19-8-10-20(30-3)11-9-19/h7-12,15-16H,4-6,13-14H2,1-3H3,(H2,25,26,27,28)
PubChem CID57401222
ChEMBLCHEMBL1922004
IUPHARN/A
BindingDB50358674
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition60.0 %PMID22018787ChEMBL

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