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GPCR

NameCannabinoid receptor 2
SpeciesHomo sapiens (Human)
GeneCNR2
SynonymPeripheral cannabinoid receptor
rCB2
hCB2
cannabinoid receptor 2 (macrophage)
cannabinoid receptor 2 (spleen)
[ Show all ]
DiseaseImmune disorder
Inflammatory bowel disease
Inflammatory disease
Neuropathic pain
Osteoporosis
[ Show all ]
Length360
Amino acid sequenceMEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProtP34972
Protein Data Bank5zty
GPCR-HGmod modelP34972
3D structure modelThis structure is from PDB ID 5zty.
BioLiPBL0438927
Therapeutic Target DatabaseT37693
ChEMBLCHEMBL253
IUPHAR57
DrugBankBE0000095

Ligand

NameCHEMBL88548
Molecular formulaC18H15Cl3N4O
IUPAC name5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N',4-dimethylpyrazole-3-carbohydrazide
Molecular weight409.695
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.2
SynonymsBDBM50114683
5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid N''-methyl-hydrazide
Inchi KeyABGHTQVGZLITLA-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H15Cl3N4O/c1-10-16(18(26)23-22-2)24-25(15-8-7-13(20)9-14(15)21)17(10)11-3-5-12(19)6-4-11/h3-9,22H,1-2H3,(H,23,26)
PubChem CID11122439
ChEMBLCHEMBL88548
IUPHARN/A
BindingDB50114683
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki6660.0 nMPMID12061874BindingDB,ChEMBL

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