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GPCR

Name5-hydroxytryptamine receptor 2C
SpeciesCanis lupus familiaris (Dog)
GeneHTR2C
Synonym5-HT-2C
5-HT2C
5-HTR2C
Serotonin receptor 2C
DiseaseN/A for non-human GPCRs
Length458
Amino acid sequenceMVNLRKAVHSFLVHLIGLLVWQCDISVSPVAALVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIILTIGGNILVIMAVSLEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPVEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIHVLRRQALMLLHGHVEEPPRINLDFLKCCRRNGTEEENSANPNQDSNPRRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLVMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKPEKKPPVRQMPRVAATALSGRELNVNIYRHTNEPVLKKANDKEPGIEMQVENLELPVNPSSVVSERISSV
UniProtQ60F97
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1770041
IUPHARN/A
DrugBankN/A

Ligand

NameKetanserin
Molecular formulaC22H22FN3O3
IUPAC name3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-1H-quinazoline-2,4-dione
Molecular weight395.434
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.6
SynonymsVulketan Gel
KS-00000XLH
74050-98-9
NCGC00021146-04
AC1L1GSK
[ Show all ]
Inchi KeyFPCCSQOGAWCVBH-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
PubChem CID3822
ChEMBLCHEMBL51
IUPHAR197, 88
BindingDB21395
DrugBankDB12465

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki13.0 nMPMID2971798BindingDB

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