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GPCR

NameProbable G-protein coupled receptor 142
SpeciesHomo sapiens (Human)
GeneGPR142
SynonymKIF19
G-protein coupled receptor PGR2
GPR142
AXOR103
DiseaseN/A
Length462
Amino acid sequenceMSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProtQ7Z601
Protein Data BankN/A
GPCR-HGmod modelQ7Z601
3D structure modelThis predicted structure model is from GPCR-EXP Q7Z601.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2069161
IUPHAR132
DrugBankN/A

Ligand

NameCHEMBL2069575
Molecular formulaC24H22N4OS
IUPAC name(2S)-3-phenyl-N-(3-pyridin-4-ylphenyl)-2-(1,3-thiazol-4-ylmethylamino)propanamide
Molecular weight414.527
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.8
SynonymsBDBM50390595
SCHEMBL2685195
Inchi KeyFPOTYKVBBGYCQW-QHCPKHFHSA-N
Inchi IDInChI=1S/C24H22N4OS/c29-24(28-21-8-4-7-20(14-21)19-9-11-25-12-10-19)23(13-18-5-2-1-3-6-18)26-15-22-16-30-17-27-22/h1-12,14,16-17,23,26H,13,15H2,(H,28,29)/t23-/m0/s1
PubChem CID67497044
ChEMBLCHEMBL2069575
IUPHARN/A
BindingDB50390595
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5067.0 nMPMID22884988BindingDB,ChEMBL
EC50970.0 nMPMID22884988BindingDB,ChEMBL

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