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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 142
Species	Homo sapiens (Human)
Gene	GPR142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A
Length	462
Amino acid sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProt	Q7Z601
Protein Data Bank	N/A
GPCR-HGmod model	Q7Z601
3D structure model	This predicted structure model is from GPCR-EXP Q7Z601.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069161
IUPHAR	132
DrugBank	N/A

Ligand

Name	CHEMBL2069575
Molecular formula	C24H22N4OS
IUPAC name	(2S)-3-phenyl-N-(3-pyridin-4-ylphenyl)-2-(1,3-thiazol-4-ylmethylamino)propanamide
Molecular weight	414.527
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.8
Synonyms	BDBM50390595 SCHEMBL2685195
Inchi Key	FPOTYKVBBGYCQW-QHCPKHFHSA-N
Inchi ID	InChI=1S/C24H22N4OS/c29-24(28-21-8-4-7-20(14-21)19-9-11-25-12-10-19)23(13-18-5-2-1-3-6-18)26-15-22-16-30-17-27-22/h1-12,14,16-17,23,26H,13,15H2,(H,28,29)/t23-/m0/s1
PubChem CID	67497044
ChEMBL	CHEMBL2069575
IUPHAR	N/A
BindingDB	50390595
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	67.0 nM	PMID22884988	BindingDB,ChEMBL
EC50	970.0 nM	PMID22884988	BindingDB,ChEMBL

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