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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesSus scrofa (Pig)
GeneHTR1D
Synonym5-HT-1D
5-HT1D
Serotonin receptor 1D
DiseaseN/A for non-human GPCRs
Length291
Amino acid sequenceAMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProtP79400
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4105
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL63713
Molecular formulaC22H21F3N4S
IUPAC name8-[4-[2-[2-(trifluoromethyl)phenyl]ethyl]piperazin-1-yl]-3-thia-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
Molecular weight430.493
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP6.0
SynonymsBDBM50407755
Inchi KeyFQHKGSXYDVSJCE-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H21F3N4S/c23-22(24,25)17-5-2-1-4-16(17)7-10-27-11-13-28(14-12-27)20-19-6-3-9-29(19)21-18(26-20)8-15-30-21/h1-6,8-9,15H,7,10-14H2
PubChem CID10717512
ChEMBLCHEMBL63713
IUPHARN/A
BindingDB50407755
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50199526.0 nMPMID8642566BindingDB,ChEMBL

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