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GPCR

NameP2Y purinoceptor 4
SpeciesHomo sapiens (Human)
GeneP2RY4
SynonymUNR
pyrimidinoceptor
pyrimidinergic receptor P2Y
P2Y4R
P2Y4 receptor
[ Show all ]
DiseaseN/A
Length365
Amino acid sequenceMASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
UniProtP51582
Protein Data BankN/A
GPCR-HGmod modelP51582
3D structure modelThis predicted structure model is from GPCR-EXP P51582.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2123
IUPHAR325
DrugBankN/A

Ligand

NameCHEMBL1767413
Molecular formulaC17H22N2O11P2S
IUPAC name[(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-oxo-2-(2-phenylethylsulfanyl)pyrimidin-1-yl]oxolan-2-yl]methyl phosphono hydrogen phosphate
Molecular weight524.374
Hydrogen bond acceptor12
Hydrogen bond donor5
XlogP-1.9
Synonyms2-phenylethylthio-1-beta-D-ribofuranosylpyrimidine-4-one-5''-diphosphate
BDBM50341884
Inchi KeyFQUNDQXKPMUPEE-DTZQCDIJSA-N
Inchi IDInChI=1S/C17H22N2O11P2S/c20-13-6-8-19(17(18-13)33-9-7-11-4-2-1-3-5-11)16-15(22)14(21)12(29-16)10-28-32(26,27)30-31(23,24)25/h1-6,8,12,14-16,21-22H,7,9-10H2,(H,26,27)(H2,23,24,25)/t12-,14-,15-,16-/m1/s1
PubChem CID52952283
ChEMBLCHEMBL1767413
IUPHARN/A
BindingDB50341884
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50100000.0 nMPMID21417463ChEMBL

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