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GPCR

NameB2 bradykinin receptor
SpeciesCavia porcellus (Guinea pig)
GeneBDKRB2
SynonymB2R
BK-2 receptor
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHKSSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGHNVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTERRATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCLNPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWARSSSEGTPPGLL
UniProtO70526
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4111
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL545765
Molecular formulaC25H22BrCl3N6O5
IUPAC nameN-[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2,4-dichlorophenyl]-N-methyl-2-[(3-nitrophenyl)carbamoylamino]acetamide;hydrochloride
Molecular weight672.742
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogPNone
SynonymsSCHEMBL8565278
Inchi KeyFRKXDPQOTNMMDP-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H21BrCl2N6O5.ClH/c1-14-23(26)33-10-4-7-20(24(33)30-14)39-13-17-18(27)8-9-19(22(17)28)32(2)21(35)12-29-25(36)31-15-5-3-6-16(11-15)34(37)38;/h3-11H,12-13H2,1-2H3,(H2,29,31,36);1H
PubChem CID18923521
ChEMBLCHEMBL545765
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC504.2 nMPMID9767642ChEMBL

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