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GPCR

NameMelanocortin receptor 4
SpeciesHomo sapiens (Human)
GeneMC4R
SynonymMC4-R
MC4 receptor
DiseaseObesity; Sexual dysfunction
Obesity; Diabetes
Obesity
Metabolic disorders
Sexual dysfunction
[ Show all ]
Length332
Amino acid sequenceMVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProtP32245
Protein Data BankN/A
GPCR-HGmod modelP32245
3D structure modelThis predicted structure model is from GPCR-EXP P32245.
BioLiPN/A
Therapeutic Target DatabaseT72458
ChEMBLCHEMBL259
IUPHAR285
DrugBankN/A

Ligand

NameMLS000699691
Molecular formulaC22H21ClN2O5
IUPAC name5-[(2-chlorophenoxy)methyl]-N-[(E)-(2,4-dimethoxy-3-methylphenyl)methylideneamino]furan-2-carboxamide
Molecular weight428.869
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP4.7
Synonyms5-[(2-chlorophenoxy)methyl]-N'-(2,4-dimethoxy-3-methylbenzylidene)-2-furohydrazide
AKOS003302279
N-[(1E)-2-(2,4-dimethoxy-3-methylphenyl)-1-azavinyl]{5-[(2-chlorophenoxy)methy l](2-furyl)}carboxamide
5-[(2-chlorophenoxy)methyl]-N-[(E)-(2,4-dimethoxy-3-methylphenyl)methylideneamino]-2-furancarboxamide
CHEMBL1994163
[ Show all ]
Inchi KeyALSZPRQIWXWJGV-WYMPLXKRSA-N
Inchi IDInChI=1S/C22H21ClN2O5/c1-14-18(27-2)10-8-15(21(14)28-3)12-24-25-22(26)20-11-9-16(30-20)13-29-19-7-5-4-6-17(19)23/h4-12H,13H2,1-3H3,(H,25,26)/b24-12+
PubChem CID6874399
ChEMBLCHEMBL1994163
IUPHARN/A
BindingDB88459
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<89207.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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