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GPCR

NameD(4) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd4
SynonymD(2C) dopamine receptor
D4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
DiseaseN/A for non-human GPCRs
Length387
Amino acid sequenceMGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProtP30729
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3361
IUPHAR217
DrugBankN/A

Ligand

NameABT-724
Molecular formulaC17H19N5
IUPAC name2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-benzimidazole
Molecular weight293.374
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.2
Synonyms70006-24-5
UNII-4WV2575JWT
ABT724
4WV2575JWT
CHEMBL440687
[ Show all ]
Inchi KeyFRPJGTNLZNXQEX-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)
PubChem CID5025739
ChEMBLCHEMBL440687
IUPHARN/A
BindingDB50145075
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5013.7 nMPMID17149874ChEMBL
EC5014.0 nMPMID17149874BindingDB
EC5014.3 nMPMID15239663BindingDB,ChEMBL
EC5023.2 nMPMID15239663BindingDB,ChEMBL
Efficacy64.0 %PMID15239663ChEMBL
Efficacy66.0 %PMID17149874ChEMBL
Efficacy70.0 %PMID15239663ChEMBL

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