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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Gastric inhibitory polypeptide receptor
Species	Homo sapiens (Human)
Gene	GIPR
Synonym	GIP-R GIP receptor Glucose-dependent insulinotropic polypeptide receptor Gippr
Disease	Type 2 diabetes
Length	466
Amino acid sequence	MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCENPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSFMLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
UniProt	P48546
Protein Data Bank	N/A
GPCR-HGmod model	P48546
3D structure model	This predicted structure model is from GPCR-EXP P48546.
BioLiP	N/A
Therapeutic Target Database	T41750
ChEMBL	CHEMBL4383
IUPHAR	248
DrugBank	N/A

Ligand

Name	aminothiazole, 5
Molecular formula	C38H34ClN3O3S
IUPAC name	3-[[4-[[N-[4-(4-chlorophenyl)-5-phenyl-1,3-thiazol-2-yl]-4-(cyclohexen-1-yl)anilino]methyl]benzoyl]amino]propanoic acid
Molecular weight	648.218
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	8.9
Synonyms	SCHEMBL2649096 CHEMBL443971 BDBM29108
Inchi Key	FTBIQPJNXCTJIU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C38H34ClN3O3S/c39-32-19-15-29(16-20-32)35-36(30-9-5-2-6-10-30)46-38(41-35)42(33-21-17-28(18-22-33)27-7-3-1-4-8-27)25-26-11-13-31(14-12-26)37(45)40-24-23-34(43)44/h2,5-7,9-22H,1,3-4,8,23-25H2,(H,40,45)(H,43,44)
PubChem CID	22496431
ChEMBL	CHEMBL443971
IUPHAR	N/A
BindingDB	29108
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1002.0 nM	PMID19385613	BindingDB,ChEMBL

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