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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL331424
Molecular formula	C23H19N3O4
IUPAC name	N-[4-(3,4-dihydro-2H-quinoline-1-carbonyl)phenyl]-3-nitrobenzamide
Molecular weight	401.422
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.0
Synonyms	N-[4-(3,4-Dihydro-2H-quinoline-1-carbonyl)-phenyl]-3-nitro-benzamide SCHEMBL7357768 BDBM50052916 FTLQHAHCNMMAKX-UHFFFAOYSA-N 1-[4-(3-nitrobenzoylamino)benzoyl]-1,2,3,4-tetrahydroquinoline
Inchi Key	FTLQHAHCNMMAKX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H19N3O4/c27-22(18-6-3-8-20(15-18)26(29)30)24-19-12-10-17(11-13-19)23(28)25-14-4-7-16-5-1-2-9-21(16)25/h1-3,5-6,8-13,15H,4,7,14H2,(H,24,27)
PubChem CID	10501216
ChEMBL	CHEMBL331424
IUPHAR	N/A
BindingDB	50052916
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	760.0 nM	PMID8784453	BindingDB,ChEMBL

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