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GPCR

NameVasopressin V1a receptor
SpeciesRattus norvegicus (Rat)
GeneAvpr1a
SynonymAVPR
AVPR V1a
AVPR1
antidiuretic hormone receptor 1a
V1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length424
Amino acid sequenceMSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
UniProtP30560
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2868
IUPHAR366
DrugBankN/A

Ligand

NameCHEMBL331424
Molecular formulaC23H19N3O4
IUPAC nameN-[4-(3,4-dihydro-2H-quinoline-1-carbonyl)phenyl]-3-nitrobenzamide
Molecular weight401.422
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.0
SynonymsBDBM50052916
FTLQHAHCNMMAKX-UHFFFAOYSA-N
1-[4-(3-nitrobenzoylamino)benzoyl]-1,2,3,4-tetrahydroquinoline
N-[4-(3,4-Dihydro-2H-quinoline-1-carbonyl)-phenyl]-3-nitro-benzamide
SCHEMBL7357768
Inchi KeyFTLQHAHCNMMAKX-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H19N3O4/c27-22(18-6-3-8-20(15-18)26(29)30)24-19-12-10-17(11-13-19)23(28)25-14-4-7-16-5-1-2-9-21(16)25/h1-3,5-6,8-13,15H,4,7,14H2,(H,24,27)
PubChem CID10501216
ChEMBLCHEMBL331424
IUPHARN/A
BindingDB50052916
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5016000.0 nMPMID8784453BindingDB,ChEMBL

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