You can:
Name | Metabotropic glutamate receptor 4 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM4 |
Synonym | mGluR4 mGlu4 receptor GPRC1D glutamate receptor |
Disease | Anxiety disorder Neurological disease |
Length | 912 |
Amino acid sequence | MPGKRGLGWWWARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIAQSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKVIGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLEAPALATKQTYVTYTNHAI |
UniProt | Q14833 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T99402 |
ChEMBL | CHEMBL2736 |
IUPHAR | 292 |
DrugBank | BE0000833 |
Name | CHEMBL1209746 |
---|---|
Molecular formula | C16H15N3O3 |
IUPAC name | ethyl 2-oxo-2-[[4-[(E)-2-phenylethenyl]pyrimidin-2-yl]amino]acetate |
Molecular weight | 297.314 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 2.7 |
Synonyms | BDBM50323584 ethyl 2-oxo-2-(4-styrylpyrimidin-2-ylamino)acetate |
Inchi Key | AMBQPEZXLSICEE-CMDGGOBGSA-N |
Inchi ID | InChI=1S/C16H15N3O3/c1-2-22-15(21)14(20)19-16-17-11-10-13(18-16)9-8-12-6-4-3-5-7-12/h3-11H,2H2,1H3,(H,17,18,19,20)/b9-8+ |
PubChem CID | 49862698 |
ChEMBL | CHEMBL1209746 |
IUPHAR | N/A |
BindingDB | 50323584 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 5000.0 nM | PMID20638279 | BindingDB,ChEMBL |
Emax | 82.0 % | PMID20638279 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218