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GPCR

Name5-hydroxytryptamine receptor 2A
SpeciesRattus norvegicus (Rat)
GeneHtr2a
Synonym5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
'D' receptor
5-HT-2A
serotonin receptor 2A
5Ht-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length471
Amino acid sequenceMEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
UniProtP14842
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL322
IUPHAR6
DrugBankN/A

Ligand

NameCHEMBL262794
Molecular formulaC19H19N3O2S
IUPAC name6-(4-methylpiperazin-1-yl)pyrrolo[2,1-b][1,3]benzothiazepine-3,5-dicarbaldehyde
Molecular weight353.44
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP2.4
SynonymsSCHEMBL6208672
BDBM50137983
9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f]azulene-1,10-dicarbaldehyde
Inchi KeyAMECFCFFHHGFQV-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H19N3O2S/c1-20-8-10-21(11-9-20)19-15-4-2-3-5-17(15)25-18-7-6-14(12-23)22(18)16(19)13-24/h2-7,12-13H,8-11H2,1H3
PubChem CID11325669
ChEMBLCHEMBL262794
IUPHARN/A
BindingDB50137983
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2300.0 nMPMID14695828BindingDB,ChEMBL

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