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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Adenosine receptor A1
Species	Homo sapiens (Human)
Gene	ADORA1
Synonym	RDC7 A1 receptor A1-AR A1R adenosine receptor A1
Disease	Cardiac arrhythmias Hypertension Cardiac disease Cognitive disorders Diabetes Fatigue; Orthostatic hypotension Glaucoma Heart failure Autoimmune diabetes Atrial fibrillation; Cardiac arrhythmias Atrial fibrillation Sepsis Renal failure Parkinson's disease Neuropathic pain Acute and chronic heart failure Multiple scierosis Hypertriglyceridemia Allergy Asthma Hyperlipidaemia [ Show all ]
Length	326
Amino acid sequence	MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
UniProt	P30542
Protein Data Bank	6d9h, 5n2s
GPCR-HGmod model	P30542
3D structure model	This structure is from PDB ID 6d9h.
BioLiP	BL0385576, BL0417675
Therapeutic Target Database	T88714, T92072
ChEMBL	CHEMBL226
IUPHAR	18
DrugBank	BE0000013

Ligand

Name	CHEMBL415697
Molecular formula	C17H16N2O
IUPAC name	1-ethyl-7-methyl-2-phenyl-1,8-naphthyridin-4-one
Molecular weight	264.328
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.4
Synonyms	1-Ethyl-2-phenyl-7-methyl-1,8-naphthyridine-4(1H)-one 1-ethyl-7-methyl-2-phenyl-1,8-naphthyridin-4(1H)-one BDBM50090692 1-Ethyl-7-methyl-2-phenyl-1H-[1,8]naphthyridin-4-one
Inchi Key	FWHOTNQFRIOUCV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H16N2O/c1-3-19-15(13-7-5-4-6-8-13)11-16(20)14-10-9-12(2)18-17(14)19/h4-11H,3H2,1-2H3
PubChem CID	10778032
ChEMBL	CHEMBL415697
IUPHAR	N/A
BindingDB	50090692
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID15163184	BindingDB,ChEMBL
Ki	501.19 nM	PMID16279775	ChEMBL

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