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GPCR

NameAdenosine receptor A3
SpeciesRattus norvegicus (Rat)
GeneAdora3
SynonymARA3
Adenosine receptor A3
A3 receptor
TGPCR1
A3AR
DiseaseN/A for non-human GPCRs
Length320
Amino acid sequenceMKANNTTTSALWLQITYITMEAAIGLCAVVGNMLVIWVVKLNRTLRTTTFYFIVSLALADIAVGVLVIPLAIAVSLEVQMHFYACLFMSCVLLVFTHASIMSLLAIAVDRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKVTLELSQNSSTLSCHFRSVVGLDYMVFFSFITWILIPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFNVKIPEIAMCLGILLSHANSMMNPIVYACKIKKFKETYFVILRACRLCQTSDSLDSNLEQTTE
UniProtP28647
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3360
IUPHAR21
DrugBankN/A

Ligand

NameCHEMBL415697
Molecular formulaC17H16N2O
IUPAC name1-ethyl-7-methyl-2-phenyl-1,8-naphthyridin-4-one
Molecular weight264.328
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.4
Synonyms1-Ethyl-2-phenyl-7-methyl-1,8-naphthyridine-4(1H)-one
1-ethyl-7-methyl-2-phenyl-1,8-naphthyridin-4(1H)-one
1-Ethyl-7-methyl-2-phenyl-1H-[1,8]naphthyridin-4-one
BDBM50090692
Inchi KeyFWHOTNQFRIOUCV-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H16N2O/c1-3-19-15(13-7-5-4-6-8-13)11-16(20)14-10-9-12(2)18-17(14)19/h4-11H,3H2,1-2H3
PubChem CID10778032
ChEMBLCHEMBL415697
IUPHARN/A
BindingDB50090692
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID10956189BindingDB,ChEMBL

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