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GLASS

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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL3656282
Molecular formula	C30H37Cl2N7O2
IUPAC name	4-[(1R)-1-[4-(3,5-dichlorophenyl)-2-methyl-2-(2-methylpropyl)-5-oxoimidazol-1-yl]-4,4-dimethylpentyl]-N-(2H-tetrazol-5-ylmethyl)benzamide
Molecular weight	598.573
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	6.5
Synonyms	US8633231, 4 BDBM113041 SCHEMBL10154362
Inchi Key	AMJNDQMIEUBXLA-DDAUYOFQSA-N
Inchi ID	InChI=1S/C30H37Cl2N7O2/c1-18(2)16-30(6)34-26(21-13-22(31)15-23(32)14-21)28(41)39(30)24(11-12-29(3,4)5)19-7-9-20(10-8-19)27(40)33-17-25-35-37-38-36-25/h7-10,13-15,18,24H,11-12,16-17H2,1-6H3,(H,33,40)(H,35,36,37,38)/t24-,30?/m1/s1
PubChem CID	56602866
ChEMBL	CHEMBL3656282
IUPHAR	N/A
BindingDB	113041
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	1100.0 nM	, None	BindingDB,ChEMBL

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