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GPCR

NameFree fatty acid receptor 3
SpeciesHomo sapiens (Human)
GeneFFAR3
SynonymFFA3R
FFA3 receptor
G-protein coupled receptor 41
GPCR41
GPR41
[ Show all ]
DiseaseN/A
Length346
Amino acid sequenceMDTGPDQSYFSGNHWFVFSVYLLTFLVGLPLNLLALVVFVGKLQRRPVAVDVLLLNLTASDLLLLLFLPFRMVEAANGMHWPLPFILCPLSGFIFFTTIYLTALFLAAVSIERFLSVAHPLWYKTRPRLGQAGLVSVACWLLASAHCSVVYVIEFSGDISHSQGTNGTCYLEFRKDQLAILLPVRLEMAVVLFVVPLIITSYCYSRLVWILGRGGSHRRQRRVAGLLAATLLNFLVCFGPYNVSHVVGYICGESPAWRIYVTLLSTLNSCVDPFVYYFSSSGFQADFHELLRRLCGLWGQWQQESSMELKEQKGGEEQRADRPAERKTSEHSQGCGTGGQVACAES
UniProtO14843
Protein Data BankN/A
GPCR-HGmod modelO14843
3D structure modelThis predicted structure model is from GPCR-EXP O14843.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5201
IUPHAR227
DrugBankN/A

Ligand

NameCHEMBL2315528
Molecular formulaC19H15NO2
IUPAC name3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]phenyl]propanoic acid
Molecular weight289.334
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.4
SynonymsSCHEMBL1551054
BDBM50425662
3-(4-((2-(cyanomethyl)phenyl)ethynyl)phenyl)propanoic acid
Inchi KeyAMKACOPNIVQTHQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H15NO2/c20-14-13-18-4-2-1-3-17(18)11-9-15-5-7-16(8-6-15)10-12-19(21)22/h1-8H,10,12-13H2,(H,21,22)
PubChem CID67072752
ChEMBLCHEMBL2315528
IUPHARN/A
BindingDB50425662
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID23294321ChEMBL

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