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GPCR

NameMelanocortin receptor 4
SpeciesHomo sapiens (Human)
GeneMC4R
SynonymMC4-R
MC4 receptor
DiseaseObesity; Sexual dysfunction
Obesity; Diabetes
Obesity
Metabolic disorders
Sexual dysfunction
[ Show all ]
Length332
Amino acid sequenceMVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
UniProtP32245
Protein Data BankN/A
GPCR-HGmod modelP32245
3D structure modelThis predicted structure model is from GPCR-EXP P32245.
BioLiPN/A
Therapeutic Target DatabaseT72458
ChEMBLCHEMBL259
IUPHAR285
DrugBankN/A

Ligand

NameMLS003124222
Molecular formulaC25H23N3O5
IUPAC nameN-[3-(4-acetylphenyl)-6-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyridin-8-yl]formamide
Molecular weight445.475
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.8
SynonymsCHEMBL1905593
SMR001292737
Inchi KeyAMKIMNGSXRZXKP-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H23N3O5/c1-15(30)16-5-7-17(8-6-16)21-12-26-25-20(27-14-29)9-19(13-28(21)25)18-10-22(31-2)24(33-4)23(11-18)32-3/h5-14H,1-4H3,(H,27,29)
PubChem CID46948689
ChEMBLCHEMBL1905593
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<89229.0 nMPubChem BioAssay data setChEMBL

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