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Name | Free fatty acid receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | CHEMBL2058521 |
---|---|
Molecular formula | C22H19FO3 |
IUPAC name | 3-[4-[[2-(4-fluorophenyl)phenyl]methoxy]phenyl]propanoic acid |
Molecular weight | 350.389 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.9 |
Synonyms | BDBM50420156 |
Inchi Key | GAELQDGHBZTWFP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H19FO3/c23-19-10-8-17(9-11-19)21-4-2-1-3-18(21)15-26-20-12-5-16(6-13-20)7-14-22(24)25/h1-6,8-13H,7,14-15H2,(H,24,25) |
PubChem CID | 57521810 |
ChEMBL | CHEMBL2058521 |
IUPHAR | N/A |
BindingDB | 50420156 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 933.25 nM | PMID22519963 | BindingDB,ChEMBL |
Efficacy | 116.0 % | PMID22519963 | ChEMBL |
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