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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V2 receptor
Species	Sus scrofa (Pig)
Gene	AVPR2
Synonym	Antidiuretic hormone receptor AVPR V2 Renal-type arginine vasopressin receptor V2R
Disease	N/A for non-human GPCRs
Length	370
Amino acid sequence	MLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGDGSGVLDCWASFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSLVPGPAERAGGHRGGRRAGSPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQEESCATASSFSARDTSS
UniProt	P32307
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3944
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL267625
Molecular formula	C54H81N9O9S2
IUPAC name	N-(8-aminooctyl)-1-[(11S,14R,17S,20R,23R)-14-(2-amino-2-oxoethyl)-20-benzyl-23-[(4-ethoxyphenyl)methyl]-13,16,19,22,25-pentaoxo-17-propan-2-yl-7,9-dithia-12,15,18,21,24-pentazaspiro[5.20]hexacosane-11-carbonyl]pyrrolidine-2-carboxamide
Molecular weight	1064.42
Hydrogen bond acceptor	12
Hydrogen bond donor	8
XlogP	5.2
Synonyms	N/A
Inchi Key	GAKFOCCTGKUAKC-WGIQCNIDSA-N
Inchi ID	InChI=1S/C54H81N9O9S2/c1-4-72-39-23-21-38(22-24-39)31-40-48(66)59-41(30-37-18-11-9-12-19-37)50(68)62-47(36(2)3)52(70)60-42(32-45(56)64)49(67)61-43(34-73-35-74-54(33-46(65)58-40)25-13-10-14-26-54)53(71)63-29-17-20-44(63)51(69)57-28-16-8-6-5-7-15-27-55/h9,11-12,18-19,21-24,36,40-44,47H,4-8,10,13-17,20,25-35,55H2,1-3H3,(H2,56,64)(H,57,69)(H,58,65)(H,59,66)(H,60,70)(H,61,67)(H,62,68)/t40-,41-,42-,43-,44?,47+/m1/s1
PubChem CID	44351386
ChEMBL	CHEMBL267625
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
K bind	310.0 nM	PMID2521519	ChEMBL

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