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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL413900
Molecular formulaC115H187N33O31
IUPAC name(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2R)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-methylamino]propanoyl]amino]-4-oxobutanoic acid
Molecular weight2527.96
Hydrogen bond acceptor36
Hydrogen bond donor36
XlogP-8.0
SynonymsN/A
Inchi KeyGANHHNSKCSETKO-MKKFXBMXSA-N
Inchi IDInChI=1S/C115H187N33O31/c1-16-61(10)91(146-95(161)63(12)129-103(169)83(53-89(157)158)137-96(162)64(13)148(15)113(179)71(118)49-67-32-36-69(152)37-33-67)111(177)141-81(50-66-26-18-17-19-27-66)107(173)147-92(65(14)151)112(178)142-82(52-87(120)155)106(172)144-85(56-150)109(175)139-80(51-68-34-38-70(153)39-35-68)105(171)135-75(31-25-45-127-115(124)125)99(165)134-73(29-21-23-43-117)102(168)145-90(60(8)9)110(176)140-78(47-58(4)5)97(163)128-54-88(156)131-76(40-41-86(119)154)101(167)138-79(48-59(6)7)104(170)143-84(55-149)108(174)130-62(11)94(160)132-74(30-24-44-126-114(122)123)98(164)133-72(28-20-22-42-116)100(166)136-77(93(121)159)46-57(2)3/h17-19,26-27,32-39,57-65,71-85,90-92,149-153H,16,20-25,28-31,40-56,116-118H2,1-15H3,(H2,119,154)(H2,120,155)(H2,121,159)(H,128,163)(H,129,169)(H,130,174)(H,131,156)(H,132,160)(H,133,164)(H,134,165)(H,135,171)(H,136,166)(H,137,162)(H,138,167)(H,139,175)(H,140,176)(H,141,177)(H,142,178)(H,143,170)(H,144,172)(H,145,168)(H,146,161)(H,147,173)(H,157,158)(H4,122,123,126)(H4,124,125,127)/t61-,62-,63-,64+,65+,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82+,83-,84-,85-,90-,91-,92-/m0/s1
PubChem CID44310575
ChEMBLCHEMBL413900
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Plasma GH release385.0 ng ml-1PMID3100799ChEMBL
Plasma GH release512.0 ng ml-1PMID3100799ChEMBL
Potency>5.0 %PMID3100799ChEMBL

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