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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Vasopressin V1a receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr1a
Synonym	AVPR AVPR V1a AVPR1 antidiuretic hormone receptor 1a V1A receptor V1aR Vascular/hepatic-type arginine vasopressin receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	424
Amino acid sequence	MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
UniProt	P30560
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2868
IUPHAR	366
DrugBank	N/A

Ligand

Name	CHEMBL118760
Molecular formula	C24H22N2O3
IUPAC name	phenyl N-[4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]carbamate
Molecular weight	386.451
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.8
Synonyms	[4-(2,3,4,5-Tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-carbamic acid phenyl ester BDBM50052939
Inchi Key	GBGCTIRNIUTZOD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C24H22N2O3/c27-23(26-17-7-6-9-18-8-4-5-12-22(18)26)19-13-15-20(16-14-19)25-24(28)29-21-10-2-1-3-11-21/h1-5,8,10-16H,6-7,9,17H2,(H,25,28)
PubChem CID	10548205
ChEMBL	CHEMBL118760
IUPHAR	N/A
BindingDB	50052939
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7800.0 nM	PMID8784453	BindingDB,ChEMBL

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