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GPCR

NameVasopressin V2 receptor
SpeciesSus scrofa (Pig)
GeneAVPR2
SynonymAntidiuretic hormone receptor
AVPR V2
Renal-type arginine vasopressin receptor
V2R
DiseaseN/A for non-human GPCRs
Length370
Amino acid sequenceMLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGDGSGVLDCWASFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSLVPGPAERAGGHRGGRRAGSPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQEESCATASSFSARDTSS
UniProtP32307
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3944
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL262499
Molecular formulaC51H74N10O10S2
IUPAC name(2S)-1-[(10S,13R,16S,19R,22R)-13-(2-amino-2-oxoethyl)-19-benzyl-22-[(4-ethoxyphenyl)methyl]-12,15,18,21,24-pentaoxo-16-propan-2-yl-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]-N-[(2R)-1,6-diamino-1-oxohexan-2-yl]pyrrolidine-2-carboxamide
Molecular weight1051.33
Hydrogen bond acceptor13
Hydrogen bond donor9
XlogP2.0
SynonymsBDBM50020656
1-[19-Benzyl-13-carbamoylmethyl-22-(4-ethoxy-benzyl)-16-isopropyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentaaza-spiro[5.19]pentacosane-10-carbonyl]-pyrrolidine-2-carboxylic acid (5-amino-1-carbamoyl-pentyl)-amide
Inchi KeyGBIDPAPOSPLFEC-YJXPDNFRSA-N
Inchi IDInChI=1S/C51H74N10O10S2/c1-4-71-34-20-18-33(19-21-34)27-36-45(65)57-37(26-32-14-7-5-8-15-32)47(67)60-43(31(2)3)49(69)58-38(28-41(53)62)46(66)59-39(30-72-73-51(29-42(63)55-36)22-10-6-11-23-51)50(70)61-25-13-17-40(61)48(68)56-35(44(54)64)16-9-12-24-52/h5,7-8,14-15,18-21,31,35-40,43H,4,6,9-13,16-17,22-30,52H2,1-3H3,(H2,53,62)(H2,54,64)(H,55,63)(H,56,68)(H,57,65)(H,58,69)(H,59,66)(H,60,67)/t35-,36-,37-,38-,39-,40+,43+/m1/s1
PubChem CID44294507
ChEMBLCHEMBL262499
IUPHARN/A
BindingDB50020656
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki9.4 nMPMID2933517BindingDB,ChEMBL
Ki37.0 nMPMID2933517BindingDB,ChEMBL

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