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GPCR

NameP2Y purinoceptor 2
SpeciesMus musculus (Mouse)
GeneP2ry2
SynonymPurinergic receptor
P2Y2 receptor
P2Y2
P2Y purinoceptor 2
ATP receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length373
Amino acid sequenceMAADLEPWNSTINGTWEGDELGYKCRFNEDFKYVLLPVSYGVVCVLGLCLNVVALYIFLCRLKTWNASTTYMFHLAVSDSLYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLHSLRWGRARYARRVAAVVWVLVLACQAPVLYFVTTSVRGTRITCHDTSARELFSHFVAYSSVMLGLLFAVPFSVILVCYVLMARRLLKPAYGTTGGLPRAKRKSVRTIALVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKITRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTEPTPSPQARRKLGLHRPNRTVRKDLSVSSDDSRRTESTPAGSETKDIRL
UniProtP35383
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075298
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL574987
Molecular formulaC8H13N2O6P
IUPAC name4-(2,4-dioxopyrimidin-1-yl)butyl dihydrogen phosphate
Molecular weight264.174
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP-1.9
SynonymsN/A
Inchi KeyGBNJFWXZTAZAOD-UHFFFAOYSA-N
Inchi IDInChI=1S/C8H13N2O6P/c11-7-3-5-10(8(12)9-7)4-1-2-6-16-17(13,14)15/h3,5H,1-2,4,6H2,(H,9,11,12)(H2,13,14,15)
PubChem CID23263379
ChEMBLCHEMBL574987
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50500000.0 nMPMID19523835ChEMBL
Inhibition60.0 %PMID19523835ChEMBL

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