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GPCR

NameNeuropeptide Y receptor type 2
SpeciesHomo sapiens (Human)
GeneNPY2R
SynonymNPY2-R
NPY-Y2 receptor
neuropeptide Y receptor type 2
Y2 receptor
DiseaseDiabetes
Metabolic disorders
Obesity
Length381
Amino acid sequenceMGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProtP49146
Protein Data BankN/A
GPCR-HGmod modelP49146
3D structure modelThis predicted structure model is from GPCR-EXP P49146.
BioLiPN/A
Therapeutic Target DatabaseT10670
ChEMBLCHEMBL4018
IUPHAR306
DrugBankBE0002419

Ligand

Name2-[4-(2-methoxyphenoxy)-3-nitrophenyl]quinoxaline
Molecular formulaC21H15N3O4
IUPAC name2-[4-(2-methoxyphenoxy)-3-nitrophenyl]quinoxaline
Molecular weight373.368
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP4.2
SynonymsAKOS001619949
MolPort-000-745-832
ZINC1109954
1-(2-methoxyphenoxy)-2-nitro-4-quinoxalin-2-ylbenzene
CHEMBL1534392
[ Show all ]
Inchi KeyAMUIZQDUZFTYFV-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H15N3O4/c1-27-20-8-4-5-9-21(20)28-19-11-10-14(12-18(19)24(25)26)17-13-22-15-6-2-3-7-16(15)23-17/h2-13H,1H3
PubChem CID1288612
ChEMBLCHEMBL1534392
IUPHARN/A
BindingDB61785
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<35430.0 nMPubChem BioAssay data setChEMBL
EC5035430.0 nMN/ABindingDB

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