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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3641738
Molecular formulaC16H16F4N4O2
IUPAC name5-fluoro-N-(4-morpholin-2-ylphenyl)-4-(2,2,2-trifluoroethoxy)pyrimidin-2-amine
Molecular weight372.324
Hydrogen bond acceptor10
Hydrogen bond donor2
XlogP2.6
SynonymsBDBM129546
SCHEMBL12610147
US8802673, 188
Inchi KeyGCGOMBVXSHFRKN-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H16F4N4O2/c17-12-7-22-15(24-14(12)26-9-16(18,19)20)23-11-3-1-10(2-4-11)13-8-21-5-6-25-13/h1-4,7,13,21H,5-6,8-9H2,(H,22,23,24)
PubChem CID68325802
ChEMBLCHEMBL3641738
IUPHARN/A
BindingDB129546
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3.3 nM, NoneBindingDB,ChEMBL

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