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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	CHEMBL1642121
Molecular formula	C25H27N3O4S
IUPAC name	6-methoxy-7-(4-methylpiperazin-1-yl)-1-naphthalen-2-ylsulfonyl-2,3-dihydroquinolin-4-one
Molecular weight	465.568
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	3.3
Synonyms	6-methoxy-7-(4-methylpiperazin-1-yl)-1-(naphthalen-2-ylsulfonyl)-2,3-dihydroquinolin-4(1H)-one BDBM50333546
Inchi Key	AMYPFPOCEWHTIS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H27N3O4S/c1-26-11-13-27(14-12-26)23-17-22-21(16-25(23)32-2)24(29)9-10-28(22)33(30,31)20-8-7-18-5-3-4-6-19(18)15-20/h3-8,15-17H,9-14H2,1-2H3
PubChem CID	53321318
ChEMBL	CHEMBL1642121
IUPHAR	N/A
BindingDB	50333546
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	165.0 nM	PMID21190848	BindingDB,ChEMBL

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