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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2262485
Molecular formula	C15H20N2O4
IUPAC name	2-[3-[(1,3-dihydroxy-2-methylpropan-2-yl)amino]propyl]isoindole-1,3-dione
Molecular weight	292.335
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	0.3
Synonyms	N/A
Inchi Key	AMZNSMGWEXFPJE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H20N2O4/c1-15(9-18,10-19)16-7-4-8-17-13(20)11-5-2-3-6-12(11)14(17)21/h2-3,5-6,16,18-19H,4,7-10H2,1H3
PubChem CID	76323071
ChEMBL	CHEMBL2262485
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Emax	54.0 %	Med Chem Res, (2009) 18:3:187	ChEMBL
IC50	80160.0 nM	Med Chem Res, (2009) 18:3:187	ChEMBL
Inhibition	5.45 %	Med Chem Res, (2009) 18:3:187	ChEMBL
Inhibition	28.4 %	Med Chem Res, (2009) 18:3:187	ChEMBL
Inhibition	54.0 %	Med Chem Res, (2009) 18:3:187	ChEMBL
Inhibition	69.2 %	Med Chem Res, (2009) 18:3:187	ChEMBL
Inhibition	100.0 %	Med Chem Res, (2009) 18:3:187	ChEMBL

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