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Name | Type-1 angiotensin II receptor |
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Species | Homo sapiens (Human) |
Gene | AGTR1 |
Synonym | Type-1 angiotensin II receptor HAT1R Agtr-1a type-1A angiotensin II receptor AT1 [ Show all ] |
Disease | Metabolic syndrome x Myocardial infarction Hypertension Restenosis Alzheimer disease [ Show all ] |
Length | 359 |
Amino acid sequence | MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE |
UniProt | P30556 |
Protein Data Bank | 6do1, 4zud, 4yay |
GPCR-HGmod model | P30556 |
3D structure model | This structure is from PDB ID 6do1. |
BioLiP | BL0312790, BL0326733, BL0439004,BL0439005 |
Therapeutic Target Database | T74456 |
ChEMBL | CHEMBL227 |
IUPHAR | 34 |
DrugBank | BE0000062 |
Name | CHEMBL306922 |
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Molecular formula | C34H37N7O4 |
IUPAC name | 5-[[benzyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]methyl]-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid |
Molecular weight | 607.715 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 5.7 |
Synonyms | BDBM50283186 5-[(Benzyl-tert-butoxycarbonyl-amino)-methyl]-2-propyl-3-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid |
Inchi Key | ANBSWLUPEDDHGK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C34H37N7O4/c1-5-11-29-35-28(22-40(33(44)45-34(2,3)4)20-23-12-7-6-8-13-23)30(32(42)43)41(29)21-24-16-18-25(19-17-24)26-14-9-10-15-27(26)31-36-38-39-37-31/h6-10,12-19H,5,11,20-22H2,1-4H3,(H,42,43)(H,36,37,38,39) |
PubChem CID | 44311567 |
ChEMBL | CHEMBL306922 |
IUPHAR | N/A |
BindingDB | 50283186 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 9.0 nM | , Bioorg. Med. Chem. Lett., (1994) 4:18:2229 | BindingDB,ChEMBL |
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